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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 416-437 doi: 10.1007/s11684-021-0852-7

Abstract: efficient valve haemodynamically, with low procedural complications that allows favourable remodelling of leftventricular (LV) structure and function.LV hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this endeavourregurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy

Keywords： surgical aortic valve replacement     trans-catheter aortic valve implantation     left ventricular hypertrophyand fibrosis     myocardial force-velocity relationship     His-Purkinje pacing     renin-angiotensin    

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Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction

Xiaoxiao Zhang,Li Yuan,Linli Qiu,Yali Yang,Qing Lv,Lin Li,Jing Wang,Lin He,Li Zhang,Xinfang Wang,Mingxing Xie,Xu Yu Jin

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 499-506 doi: 10.1007/s11684-016-0473-8

Abstract:

Contrast echocardiography with left ventricular opacification (LVO) improves the definition of endocardiumThis study was aimed to determine whether LVO offered added diagnostic value in noncompaction of leftventricular myocardium (NCVM).

Keywords： echocardiography     left ventricular noncompaction cardiomyopathy     echo contrast media    

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Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 71-76 doi: 10.1007/s11684-010-0006-9

Abstract: development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing leftventricular (LV) torsion.This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patientsThis study demonstrated that 2D strain has a potential ability for quantification of left ventricular

Keywords： echocardiography     twist     two-dimensional strain imaging     coronary artery disease    

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Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 70-78 doi: 10.1007/s11684-020-0749-x

Abstract: To investigate the effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular

Keywords： myocardial infarction     percutaneous coronary intervention     diabetes mellitus     fasting glucose     heart failure    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiac hypertrophyThe ratio of left ventricle weight to body weight (LV/BW) of the rats in pAT1a-shRNA1, pAT1a-shRNA2,targeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac hypertrophy

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 75-84 doi: 10.1007/s11684-022-0950-1

Abstract: all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo leftTo best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main8.6, 72% male), 52% of whom had acute coronary syndrome, underwent leftNo procedural mortality and no acute closures of the treated left main occurred.Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one

Keywords： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary    

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Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline

Houjuan Zuo, Rui Li, Fei Ma, Jiangang Jiang, Kun Miao, Haojie Li, Eike Nagel, Marijana Tadic, Hong Wang, Dao Wen Wang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 284-292 doi: 10.1007/s11684-019-0713-9

Abstract: In this study, changes in the left ventricular ejection fraction (LVEF) and global and layer-specificconclusion, FM patients who received mechanical circulatory supports exhibited steep improvement in ventricular

Keywords： fulminant myocarditis     acute myocarditis     2D speckle tracking echocardiography     left ventricular function    

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Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosisInflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key

Keywords： peritoneal dialysis     peritoneal fibrosis     inflammation     angiogenesis    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisand intervention of resveratrol as well as the way by which integrin-β1 promoted hepatic fibrosis.Hepatic fibrosis models of male Sprague Dawley (SD) rats were created and intragastric administrationLiver function and pathological sections of each group in different stages of hepatic fibrosis was testedas the development of hepatic fibrosis.

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failureThe purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis.We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC).In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacSildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 338-342 doi: 10.1007/s11684-007-0065-8

Abstract: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a kind of primary myocardial disease characterizedby the regional or global replacement of right ventricular myocardium by fatty and fibrolipomatous tissuesOne of the victims had extensive and severe pathological changes in his heart involving the left ventricularwall as well as the ventricular septum and the right atrium.Not only was there a global fatty and fibrolipomatous tissue replacement of the right ventricular myocardia

Keywords： sarcoplasmic coagulation     acquired     ventricular myocardium     sino-atrial     autopsied    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract:

Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events.A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) wasResults indicated that aspirin treatment abrogated the increased thickness of the left ventricular anteriormitochondria, and the increased surface area in in vivo and in vitro hypertrophy

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 550-558 doi: 10.1007/s11684-017-0567-y

Abstract:

Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CF transmembrane

Keywords： cystic fibrosis     pseudo-Bartter syndrome     hypokalemic alkalosis     CFTR gene     mutations     infants     diagnosis    

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Evaluation of potential failure of rock slope at the left abutment of Jinsha River Bridge by model test

Zhiming ZHAO, Xihua WANG

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 3,   Pages 332-340 doi: 10.1007/s11709-013-0206-x

Abstract: The left bank slope composes of moderately thick layer of slate overlain by schistose basalt, and where

Keywords： slope stability     strength properties     model test     numerical analysis    

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Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 314-316 doi: 10.1007/s11684-008-0060-8

Abstract: The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats.A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin.Feixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.

Keywords： bleomycin     intratracheal injection     prednisone     collagen     bleomycin-induced pulmonary    

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Title Author Date Type Operation

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following

Journal Article

Incremental value of contrast echocardiography in the diagnosis of left ventricular noncompaction

Xiaoxiao Zhang,Li Yuan,Linli Qiu,Yali Yang,Qing Lv,Lin Li,Jing Wang,Lin He,Li Zhang,Xinfang Wang,Mingxing Xie,Xu Yu Jin

Journal Article

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

Journal Article

Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

Journal Article

Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline

Houjuan Zuo, Rui Li, Fei Ma, Jiangang Jiang, Kun Miao, Haojie Li, Eike Nagel, Marijana Tadic, Hong Wang, Dao Wen Wang

Journal Article

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on

Zhen Zhang, Na Jiang, Zhaohui Ni

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports

CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou

Journal Article

Evaluation of potential failure of rock slope at the left abutment of Jinsha River Bridge by model test

Zhiming ZHAO, Xihua WANG

Journal Article

Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

ZHANG Xiaomei, JIANG Liangduo, ZHANG Wei, WU Jianjun, LU Xiangfeng

Journal Article